NIH

Highly active antiretroviral therapy (HAART) has been extremely effective at slowing the progression of HIV infection to AIDS as well as extending the lives and improving the quality of life for those with HIV. However, some doctors have been reluctant to prescribe HAART to HIV-infected injection drug users because of concern that they may not fully benefit from the therapy. A new study by investigators funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, and led by the British Columbia Centre for Excellence in HIV/AIDS in Canada, suggests that this is not the case: in their large, community-based study of HIV-infected people, injection drug users and people who did not inject drugs had equivalent survival rates seven years after initiating HAART. These results will be published August 6 in the Journal of the American Medical Association.

The NIDA NewsScan #54 examines the latest findings on drug abuse among youth as well as key issues including the relationship between marijuana and the perception of pain, the role emotions play in smoking, and innovative approaches to pain management through virtual reality. The National Institute on Drug Abuse (NIDA) is part of the National Institutes of Health (NIH).

High-dose injections of vitamin C, also known as ascorbate or ascorbic acid, reduced tumor weight and growth rate by about 50 percent in mouse models of brain, ovarian, and pancreatic cancers, researchers from the National Institutes of Health (NIH) report in the August 5, 2008, issue of the "Proceedings of the National Academy of Sciences." The researchers traced ascorbate's anti-cancer effect to the formation of hydrogen peroxide in the extracellular fluid surrounding the tumors. Normal cells were unaffected.

"For Women with Diabetes: Your Guide to Pregnancy" is an illustrated, 44-page booklet that includes information about checking and controlling blood glucose -- also called blood sugar levels, maintaining a healthy diet, staying physically active and taking tests and diabetes medications during pregnancy. The importance of planning for pregnancy and getting blood glucose levels under control before pregnancy to decrease the risk of birth defects associated with diabetes is emphasized. Logs for recording daily blood glucose and ketone levels, food intake and physical activity are included.

As published in the August issue of the journal "Biosensors and Bioelectronics," a team of researchers supported by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, report they have developed an ultra-sensitive optical protein sensor, a first for a salivary diagnostic test. The sensor can be integrated into a specially designed lab-on-a-chip, or microchip assay, and preprogrammed to bind a specific protein of interest, generating a sustained fluorescent signal as the molecules attach. A microscope then reads the intensity of the fluorescent light -- a measure of the protein's cumulative concentration in the saliva sample -- and scientists gauge whether it corresponds with levels linked to developing disease.

Scientists using a three-dimensional cell culture system have identified a mechanism by which dormant, metastatic tumor cells can begin growing again after long periods of inactivity. The new findings indicate that the switch from dormancy to proliferative, metastatic growth may be regulated, in part, through signaling from the surrounding microenvironment, which leads to changes in the skeletal architecture of dormant tumor cells. Targeting this mechanism may also provide strategies for inhibiting the switch from dormancy to proliferation. The results of this study by National Cancer Institute (NCI) scientists and their collaborators, appears in the August 1, 2008, issue of

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) has published several new resources to help people learn more about urologic and kidney disorders. These disorders are among the most critical health problems in the United States, affecting millions of Americans, including children and young adults. The publications address interstitial cystitis/painful bladder syndrome (IC/PBS), urinary tract infections (UTIs) in children, prostatitis, IgA nephropathy, and home hemodialysis.

Hyperthermia is the name given to a variety of heat-related illnesses that can include heat stroke, heat fatigue, heat syncope (sudden dizziness after exercising in the heat), heat cramps and heat exhaustion. Older adults are particularly at risk for developing heat-related illness because the ability to adequately respond to summer heat can become less efficient with age. The National Institute on Aging (NIA), part of the National Institutes of Health (NIH), has some advice for helping older people avoid heat problems during the summer months.

Drug addiction dramatically shifts a person's attention, priorities, and behaviors towards a focus almost entirely on seeking out and taking drugs. Now, an animal study funded by the National Institute on Drug Abuse, part of the National Institutes of Health, has identified some of the specific long-term adaptations in the brain’s reward system that may contribute to this shift. These long-lasting brain changes may underlie the maladaptive learning that contributes to addiction and to the propensity for relapse, even after years of abstinence from the drug. The study was published in "Neuron" on July 30, 2008.

Researchers have pinpointed a mechanism in the brains of mice that could explain why some human mothers become depressed following childbirth. The discovery could lead to improved treatment for postpartum depression. Supported in part by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, the study used genetically engineered mice lacking a protein critical for adapting to the sex hormone fluctuations of pregnancy and the postpartum period.

A new study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts.

In recent years, a class of small molecules known as microRNAs have been found to play an important role in regulating gene products in most animal and plant species. A new study now indicates that microRNA may influence the development of alcohol tolerance, a hallmark of alcohol abuse and dependence. Researchers supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, report the findings in the July 31, 2008 issue of the journal "Neuron."

People with schizophrenia bear an "increased burden" of rare deletions and duplications of genetic material, genome-wide, say researchers supported in part by the National Institute of Mental Health (NIMH), a component of the National Institutes of Health (NIH).

The use of advanced imaging techniques has allowed researchers to visualize how a key part of the human immunodeficiency virus (HIV) changes shape after binding to immune system cells or to infection-fighting antibodies. Although scientists had been able to visualize individual components of this part of the virus, called the HIV spike, the new research characterizes, for the first time, the structure of the intact spike on virus particles, which is a crucial piece of knowledge that may aid the design of new vaccines or drugs to fight HIV infection. The research was conducted by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health. The results were published online July 30, 2008, in "Nature."

Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cells can inhibit the growth of breast cancer cells that migrate to the brain. The small molecule used in the studies was the drug lapatinib (Tykerb), which disrupts an important breast cancer metabolic process called the Her2/neu signaling pathway. Lapatinib inhibits the activation of growth signaling proteins and their signaling pathways as well as cell migration and proliferation. Using the mouse model, the drug reduced the number of brain lesions that resulted from the injection of human cells. The study, which appeared online July 29, 2008, in the "Journal of the National Cancer Institute," was conducted by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).

A promising new drug therapy used to treat abnormal swelling in the eye -- a condition called diabetic macular edema -- proved less effective than traditional laser treatments in a study funded by the National Eye Institute (NEI), part of the National Institutes of Health (NIH). The study, published online in July in the journal "Ophthalmology," demonstrates that laser therapy is not only more effective than corticosteroids in the long term treatment of diabetic macular edema, but also has far fewer side effects.

The Fogarty International Center, the global arm of the National Institutes of Health, today launched a $1.5 million-a-year grant program to fund domestic and overseas training of researchers to fight chronic diseases in developing nations.

For the first time, a strategic plan for research into benign prostate disease, based on the latest scientific knowledge, has been published by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH). The NIDDK Prostate Research Strategic Plan is the culmination of discussions and meetings among experts over the past two years in an effort to outline a strategic vision for research into these elusive and multi-faceted diseases.

A consortium of researchers from the United States, Canada, and Europe has identified 21 new genes for Crohn’s disease, a chronic disease of the large and small intestines. This discovery, funded in part by the National Institutes of Health (NIH), brings the total number of known genes associated with Crohn's disease to more than 30 and advances understanding of causes and potential avenues to develop new treatments.

After soliciting and considering broad input from the scientific and HIV advocacy communities, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has determined that it will not conduct the HIV vaccine study known as PAVE 100. However, NIAID believes the vaccine developed by its Vaccine Research Center (VRC) is scientifically intriguing and sufficiently different from previously tested HIV vaccines to consider testing it in a smaller, more focused clinical study.